association between interlukin-6 (il-6), interlukin-10 (il-10) and depression in patients undergoing hematopoietic stem cell transplantation.

the release of pro-inflammatory cytokines is responsible for the variety of behavioral, neuro-endocrine and neuro-chemical alterations in psychiatric condition. in this study we evaluate relation between depression and il-6 and il-10 in patients undergoing hematopoietic stem cell transplantation (hsct).66 patients in this cross-sectional study from july 2013 until august 2014 for hsct interred the study and were assessed for depression using hospital anxiety and depression scale (hads). serum interleukin (il)-6, (il)-10 and high sensitive c-reactive protein (hs-crp) were assessed on the same time. association between these biomarkers with depression was evaluated using spss version 20.a total of 66 patients with the mean age of 41.18+13.92 and 41.95+12.35 years old in non depressed and depressed group respectively were enrolled in this study. patients with depression showed significantly higher levels of serum il-6 and the il-6-to-il-10 ratio compared to patients without depression (p<0.001).there was no statistically significant association between il-10 and hs-crp with depression in this group of the patients.high il-6 level has significant association with depression in patients undergoing hsct. in conclusion, since il-6 can affect the outcomes after hsct and depression was associated with increased serum il-6 level, early identification of depression can be beneficial in these patients.